About

I am a pharmacist and biomedical scientist, with a research focus on the application of NMR spectroscopy-based metabolic profiling (metabolomics) to cell systems related to brain disorders, corals, and other living organisms.

My teaching centres on quantitative data analysis and genetics, and also extends into other biomedical and forensic areas.

Teaching responsibilities

I currently lead the following modules:

• 4BY535 Clinical Genetics (for first-year Human Biology, Forensic and Biomedical Science students);
• 7FO508 Research Methods and Data Interpretation (for Master of Research in Molecular Medicine, Master of Science in Forensic Science, and Master of Science in Biomedical Science students).

As Industrial Placement Lead, I am the main point of contact for second-year Biomedical and Forensic Science students who are planning to undertake a year in industry before their final year at university. I also contribute to the placement year module:

• 5PL019 (for Biology, Zoology, Psychology, Biomedical Science, Sports Science, and Forensic Science students on industrial placement).

I also teach sessions across various forensic and biomedical science modules, including statistics using Excel, SPSS and R, personalised medicine, anatomy and physiology, and antibiotics.

Professional interests

I have a strong drive to improve my teaching and research practice; I have recently been awarded the Academic Professional Leadership Apprenticeship, FHEA and PGCert.

Research interests

Although NMR-based metabolic profiling can be applied to any complex biological system, my main research topic centres around an aggressive and currently untreatable brain tumour glioblastoma.

Using cell culture model, I try to capture the interaction between brain tumour cells and its microenvironment, including brain cells such as microglia and astrocytes. My studies aim to identify how the interaction between these cells and other factors in the tumour microenvironment support tumour growth by looking at metabolic changes as a read-out for cellular function.

Membership of professional bodies

• General Pharmaceutical Council - Registered Pharmacist
• Biochemical Society - Early Career Membership

Qualifications

• MPharm (Universty of Innsbruck, Austria) - pharmacist (registered in the UK) 
• PhD in Life Sciences (University of Nottingham, UK)
• Postgraduate Certificate in Academic Practice and Leadership FHEA
• AFHEA, FHEA
• Certificate from Skills England (Academic Practice and Leadership Apprenticeship with Specialist role in Teaching)

Recent conferences

Metabolomics and Human Health Gordon Research Conference and Seminar 

Recent publications

• 2024 - A convenient model of serum-induced reactivity of human astrocytes to investigate astrocyte-derived extracellular vesicles, White, K. E., et al.; Frontiers in Cellular Neuroscience 18.

• 2020 - CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model; Ketley A et al.; Science Translational Medicine. 2020 Apr 29;12(541): eaaz2415 

• 2018 - Dynamic metabolic patterns tracking neurodegeneration and gliosis following 26S proteasome dysfunction in mouse forebrain neurons; Geiszler PC, Ugun-Klusek A, Lawler K, Pardon MC, Yuchun D, Bai L, Daykin CA, Auer DP, Bedford L; Scientific Reports. 2018 Mar 19; 8 (1): 4883
• 2018 - NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy; Rossi F, Geiszler PC, Meng W, Barron MR, Prior M, Herd-Smith A, Loreto A, Yanez Lopez M, Faas H, Pardon MC, Conforti L; Behavioural Brain Research. 2018 Feb 26; 339: 140 – 152
• 2016 - Impaired burrowing is the most prominent behavioral deficit of aging htau mice;
  Geiszler PC, Barron MR, Pardon MC; Neuroscience. 2016 Aug 4; 329: 98 – 111
• 2016 - A novel role for the immunophilin FKBP52 in motor coordination;
  Young MJ*, Geiszler PC*, Pardon MC; Behavioural Brain Research. 2016 Oct 15; 313: 97 – 110. *joint first authors
• 2013 - The journey from metabolic profiling to biomarkers: the potential of NMR spectroscopy based metabolomics in neurodegenerative disease research; Geiszler PC, Auer DP and Daykin CA; Current Metabolomics. 1(2): 160 – 179